Thermo Fisher Scientific IRF7 Polyclonal Antibody
Rabbit polyclonal antibody for detection of IRF7 protein. Validated for Western blot at 1–2 µg/mL. Recognizes peptide near the center of human IRF7. Suitable positive controls include spleen, thymus, or peripheral blood leukocytes. For research use only.
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- PA112811
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- pk
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Applications
- Western Blot (WB): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide corresponding to 14 residues near the center of human IRF7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2127555 |
Product Specific Information
A suggested positive control for this product is spleen, thymus, or peripheral blood leukocytes.
Target Information
Interferons (IFNs) are involved in numerous immune interactions during viral infections and play a major role in the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions activate transcription factors such as IRF3, which stimulate transcription of IFN-α/β genes.
IRF7 is essential for the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. It plays a major role in the innate immune pathway by interacting with Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM, functioning as an intermediate in TLR4 and TLR9 signaling.
There are at least four differentially spliced isoforms of IRF7, though their specific functions have not been clearly established.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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