Thermo Fisher Scientific GTF2H2/BTF2/TFIIH Basal Transcription Factor Monoclonal Antibody (PCRP-GTF2H2-1B9)
TFIIH 복합체 구성요소인 GTF2H2 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. ICC/IF, Flow Cytometry, Peptide Array 등 다양한 응용에 적합합니다. 단백질 A/G로 정제된 액상 형태이며, 보존제가 없습니다.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–2 µg/mL
Flow Cytometry (Flow)
- Tested Dilution: 1–2 µg/10^6 cells
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | PCRP-GTF2H2-1B9 |
| Immunogen | Recombinant full-length human GTF2H2 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Initiation of transcription from protein-coding genes in eukaryotes is a complex process requiring RNA polymerase II and basal transcription factors. Binding of TFIID (TBP) to the TATA box initiates formation of a multiprotein complex containing TFIIA, TFIIB, TFIIE, TFIIF, and TFIIH.
TFIIH (also known as BTF2) is a multisubunit transcription/DNA repair factor with several enzymatic activities. The core of TFIIH includes five subunits: p89 (XPB/ERCC3), p62, p52, p44, and p34. Additional subunits include p80 (XPD/ERCC2) and a kinase complex composed of Cdk7, cyclin H, and MAT1. Both p89 and p80 possess ATP-dependent helicase activity, while p62, p52, and p44 are involved in nucleotide excision repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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