Thermo Fisher Scientific BST2 Polyclonal Antibody, Biotin
BST2 단백질을 인식하는 Biotin 결합 토끼 다클론 항체로, WB, IHC, ICC, ELISA, IP 등 다양한 응용에 적합합니다. 인간, 마우스, 랫트에 반응하며, Affinity chromatography로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- BST2-11-BIOTIN
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| Immunocytochemistry (ICC/IF) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
| Immunomicroscopy (IM) | 1:50–1:200 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Mid-region synthetic peptide within amino acid region 50–100 of human bone marrow stromal antigen 2 (BST2/CD317) protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
BST2 (also known as CD317, HM1.24 antigen, DAMP-2, tetherin) is an integral membrane protein involved in B-cell development and growth. Its surface expression on fibroblast cell lines supports stromal cell-dependent growth of pre-B-cell lines. BST2 is highly expressed during B-cell maturation, as well as in T-cells, monocytes, NK cells, dendritic cells, and myeloma cells.
Research indicates BST2 acts as an inhibitor of retrovirus release from human cells, a process antagonized by the HIV-1 accessory protein Vpu. BST2 retains virions on cell surfaces or internalizes them into BST2-positive compartments. Depletion of BST2 eliminates the viral requirement for Vpu in virus release, suggesting a potential therapeutic target for HIV/AIDS. BST2 dysfunction has also been linked to stomatitis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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