Thermo Fisher Scientific NOX2 Polyclonal Antibody
Human NOX2 단백질에 특이적인 다클론 항체로, IHC(P)에서 1–2 µg/mL 농도로 사용 가능. Goat에서 유래한 IgG 형태이며, 0.5 mg/mL 농도의 액상 제품. TBS(pH 7.3) 버퍼에 0.5% BSA 포함, -20°C 보관. 연구용으로만 사용.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (SYLNFARKRIKNP) corresponding to the internal amino acids of CYBB (aa 151–164) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_10985441 |
Product Specific Information
- This antibody is predicted to react with canine based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
Mox1 and the glycoprotein gp91-phox are largely related proteins that are essential components of the NADPH oxidase complex. This complex generates superoxide and is expressed in phagocytes, neuroepithelial bodies, vascular smooth muscle cells, and endothelial cells. It includes a membrane-bound flavocytochrome with two subunits (gp91-phox and p22-phox) and cytosolic proteins (p47-phox and p67-phox). The p22 and gp91-phox subunits also function as surface O₂ sensors that initiate cellular signaling in response to hypoxia.
Mox1 and gp91 share identical C-terminal sequence identity but have distinct expression patterns. gp91-phox is expressed in eosinophils, neutrophils, monocytes, and B-lymphocytes, while Mox1 is predominantly detected in the colon, with low expression in the uterus and prostate.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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