Thermo Fisher Scientific DMP1 Polyclonal Antibody

Thermo Fisher Scientific DMP1 Polyclonal Antibody

Applications

• Western Blot (WB)
  Tested Dilution: 1–3 µg/mL
  View 1 publication

Product Specifications

Product Specific Information

This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.

Target Information

Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein belonging to the small integrin-binding ligand N-linked glycoprotein family. It plays a critical role in the mineralization of bone and dentin and is expressed in various bone and tooth tissue cells.
The protein features multiple acidic domains, phosphorylation sites, a functional Arg-Gly-Asp (RGD) cell attachment sequence, and a DNA-binding domain.
In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon maturation, it becomes phosphorylated and relocates to the extracellular matrix to promote mineralized matrix formation.
Mutations in the DMP1 gene cause autosomal recessive hypophosphatemia, leading to rickets and osteomalacia. The gene structure is conserved among mammals, with two known transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.