Thermo Fisher Scientific DMP1 Polyclonal Antibody
DMP1 단백질을 인식하는 Goat Polyclonal 항체로, Western Blot에 최적화되어 있습니다. 인간 시료 반응성이 있으며, 0.5 mg/mL 농도의 액상 형태로 제공됩니다. 뼈와 치아 조직의 미네랄화 연구에 활용됩니다.
- 카탈로그번호
- PA519009
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific DMP1 Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1–3 µg/mL
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (ENSEQANTQDSG) corresponding to the internal amino acids of DMP1 (aa 244–256) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10988659 |
Product Specific Information
This antibody is tested in Peptide ELISA: antibody detection limit dilution 4,000.
Target Information
Dentin matrix acidic phosphoprotein (DMP1) is an extracellular matrix protein belonging to the small integrin-binding ligand N-linked glycoprotein family. It plays a critical role in the mineralization of bone and dentin and is expressed in various bone and tooth tissue cells.
The protein features multiple acidic domains, phosphorylation sites, a functional Arg-Gly-Asp (RGD) cell attachment sequence, and a DNA-binding domain.
In undifferentiated osteoblasts, DMP1 acts as a nuclear protein regulating osteoblast-specific gene expression. Upon maturation, it becomes phosphorylated and relocates to the extracellular matrix to promote mineralized matrix formation.
Mutations in the DMP1 gene cause autosomal recessive hypophosphatemia, leading to rickets and osteomalacia. The gene structure is conserved among mammals, with two known transcript variants encoding distinct isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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