Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI1C9), TrueMAB

Thermo Fisher Scientific F13A1 Monoclonal Antibody (OTI1C9), TrueMAB

Applications

• Western Blot (WB)

Tested Dilution: 1:2,000

Product Specifications

Additional Formats

• Biotin
• Request custom conjugation

Product Specific Information

For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

This gene encodes the coagulation factor XIII A subunit.
Coagulation factor XIII is the final zymogen activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of two A subunits (catalytic) and two B subunits (carrier). Platelet factor XIII contains only two A subunits identical to plasma origin.
Upon thrombin activation and calcium presence, factor XIII dissociates its B subunits and forms the active enzyme factor XIIIa, which catalyzes gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, stabilizing the clot.
Deficiency types:

• Type I: Lack of both A and B subunits
• Type II: Lack of A subunit only
  These defects can cause lifelong bleeding tendency, poor wound healing, and recurrent miscarriage.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.