Thermo Fisher Scientific Noxa Polyclonal Antibody
인간, 마우스, 랫트 반응성을 가진 Noxa 폴리클로날 항체로 다양한 IHC, ICC, ELISA 실험에 사용 가능. KLH 결합 합성 펩타이드(aa 21-54)를 면역원으로 제작. 고순도 Protein A 정제, 액상 형태, -20°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC-P) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human Noxa (amino acids 21–54) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Apoptosis is related to many diseases and developmental processes. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes including p53R2, p53AIP1, and PUMA. A newly identified p53 target gene, Noxa, encodes a protein belonging to the BH3-only proapoptotic subfamily. Both Noxa and PUMA are transcriptional targets of p53 and BH3-only proteins.
X-ray irradiation increases p53-dependent Noxa mRNA and protein levels. When ectopically expressed, Noxa interacts with anti-apoptotic Bcl-2 family members, activating caspase-9. Like PUMA, Noxa localizes to mitochondria and induces apoptosis in response to p53. Noxa and PUMA may act as direct mediators of p53-induced apoptosis. Elevated levels of p53 and Noxa are associated with impaired tumor development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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