Thermo Fisher Scientific TNNT1 Polyclonal Antibody
Human TNNT1 단백질을 인식하는 Goat Polyclonal Antibody로, WB 및 IHC(P) 응용에 적합. 모든 보고된 isoform을 인식하며 높은 특이성과 민감도 제공. 연구용으로만 사용 가능하며 안정적인 액상 형태로 제공.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.03–0.1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 5 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide with sequence C-EKAQELSDWIHQLE (aa 221–234) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2933651 |
Product Specific Information
- Expected to recognize all reported isoforms (NP_003274.3; NP_001119604.1; NP_001119605.1).
- Tested in Peptide ELISA: antibody detection limit dilution 1:128,000.
Target Information
This gene encodes a protein that is a subunit of troponin, a regulatory complex located on the thin filament of the sarcomere. The complex regulates striated muscle contraction in response to intracellular calcium concentration changes. It consists of three subunits:
- Troponin C: binds calcium
- Troponin T: binds tropomyosin
- Troponin I: inhibitory subunit
This protein is the slow skeletal troponin T subunit. Mutations in this gene cause nemaline myopathy type 5 (Amish nemaline myopathy), a neuromuscular disorder characterized by muscle weakness and rod-shaped inclusions in skeletal muscle fibers, often fatal in infancy due to respiratory insufficiency. Multiple transcript variants encoding different isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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