Thermo Fisher Scientific MIA Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• The immunizing peptide represents the N terminus of the mature protein.
• This antibody is tested in Peptide ELISA: antibody detection limit dilution 1:64,000.

Target Information

Tumorigenesis is a process mediated by a network of membrane, cytosolic, and nuclear-associated factors that regulate proliferation and cell-matrix interactions through signaling cascades. The phenotype of malignant melanomas in vivo depends on the global expression of stimulatory or inhibitory factors generated in both the tumor cells and their environment.

Melanoma inhibitory activity (MIA), also known as cartilage-derived retinoic acid-sensitive protein (CD-RAP), is an SH3-like domain-containing protein secreted from chondrocytes and malignant melanoma cells. MIA is translated as a 131-amino acid pro-form and processed into a mature 107-amino acid protein after cleavage of a secretion signal. It is expressed during chondrogenesis and in mature chondrocytes, suggesting a role in maintaining normal cartilage cell phenotype. MIA mRNA is present in carcinomas of the colon, ovary, kidney, and head/neck, and may serve as a marker to monitor melanomic activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.