Thermo Fisher Scientific DTNA Monoclonal Antibody (OTI1B11), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The DTNA gene encodes a protein belonging to the dystrobrevin subfamily of the dystrophin family.
This protein is a component of the dystrophin-associated protein complex (DPC), which includes dystrophin and several integral and peripheral membrane proteins such as dystroglycans, sarcoglycans, syntrophins, and alpha- and beta-dystrobrevin.
DPC localizes to the sarcolemma, and its disruption is linked to various muscular dystrophies.
Mutations in DTNA are associated with left ventricular noncompaction and congenital heart defects.
Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.