Thermo Fisher Scientific MAPK7 Monoclonal Antibody (OTI4C1), TrueMAB

Applications

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

MAPK7 (ERK5) serine/threonine kinase is part of the MAP kinase family and plays roles in cell proliferation, differentiation, transcription regulation, and development.
Activated by MAP2K5/MEK5, MAPK7 mediates downstream signaling and translocates to the nucleus to regulate gene expression through phosphorylation of transcription factors.
MAPK7 gene deletion in mice leads to defective vascular and cardiac development, resulting in embryonic lethality.
ERK5 is expressed in adult tissues such as heart, placenta, lung, kidney, and skeletal muscle, but not in liver.
Four alternatively spliced transcript variants encoding two distinct isoforms have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.