Thermo Fisher Scientific Phospho-PDGF Receptor beta (Tyr751) Polyclonal Antibody
PDGFRB (Tyr751) 인산화 형태를 인식하는 Rabbit Polyclonal Antibody로, 인간 및 생쥐 시료에 반응. Western blot에 최적화된 항체로 높은 특이성과 재현성을 제공. 항원 친화 크로마토그래피로 정제되어 안정적이며, 연구용으로 적합.
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Thermo Fisher Scientific Phospho-PDGF Receptor beta (Tyr751) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human PDGF Receptor beta (phospho Tyr751). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7, with 20% glycerol, 1% BSA |
| Contains | 0.025% ProClin 300 |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2902018 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
PDGFRB is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The growth factor bound to a receptor monomer determines whether the receptor forms a homodimer or heterodimer, composed of PDGF receptor alpha and beta polypeptides.
The PDGFRB gene is located on chromosome 5 near genes for granulocyte-macrophage colony-stimulating factor and macrophage colony-stimulating factor receptor, which may be involved in the 5-q syndrome.
A translocation between chromosomes 5 and 12 that fuses PDGFRB (CD140b) with the ETV6 leukemia gene results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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