Thermo Fisher Scientific Phospho-PDGF Receptor beta (Tyr1021) Polyclonal Antibody
PDGFRB (Tyr1021) 인산화 부위를 인식하는 Rabbit Polyclonal 항체. Human 및 Mouse 시료에 반응. Western blot에 최적화되어 있으며, 항원 친화 크로마토그래피로 정제됨. -20°C 보관, ProClin 300 함유.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human PDGF Receptor beta (phospho Tyr1021). The exact sequence is proprietary. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.63 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2902017 |
Product Specific Information
- Centrifuge briefly prior to opening.
Target Information
PDGFRB is a receptor tyrosine kinase and has been implicated in atherogenesis and in cell transformation by the SIS oncogene. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides.
The gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses PDGFRB (CD140b) to that of the translocation, ETV6 leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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