Thermo Fisher Scientific CDCA8 Polyclonal Antibody
CDCA8 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 사용 가능. 인간 시료 반응성, 항원 친화 크로마토그래피로 정제. 세포 분열 및 암 연구용으로 적합.
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Applications 및 Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CDCA8. Recombinant protein control fragment (Product #RP-94215) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2639578 |
Product Specific Information
Immunogen sequence:
PLKSAKTRKV IQVDEMIVEE EEEEENERKN LQTARVKRCP PSKKRTQSIQ GKGKGKRSSR ANTVTPAVGR LEVSMVKPTP GLTPRFDSR
Highest antigen sequence identity to the following orthologs:
- Mouse: 64%
- Rat: 66%
Target Information
CDCA8 is a component of the chromosomal passenger complex (CPC) required for stability of the bipolar mitotic spindle. The CPC, which includes Survivin, CDCA8, INCENP, and Aurora-B, plays crucial roles during mitosis and cell division. CDCA8 interacts with Aurora-B, INCENP, and Survivin, increasing during G2/M phase and decreasing after exit from M phase. It is cell cycle regulated, down-regulated by p53/Rb signaling, and up-regulated in many cancerous tissues.
In Drosophila cells, inactivation of CDCA8 results in polyploidy, delayed mitosis, and abnormal tissue development, indicating its critical role in cell proliferation. CDCA8 is essential for early embryonic development, and its aberrant expression is linked to poor prognosis in gastric cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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