Thermo Fisher Scientific THEM4 Polyclonal Antibody
Human THEM4 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 장기 보관 시 -20°C에서 안정적. PKB/Akt 조절 연구 및 암 관련 기전 분석에 활용 가능.
- 판매단위
- pk
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human THEM4. Recombinant protein control fragment (Product #RP-94335) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.05 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648434 |
Product Specific Information
Immunogen sequence:
PPGFIHGGAI ATMIDATVGM CAMMAGGIVM TANLNINYKR PIPLCSVVMI NSQLDKVEGR KFFVSCNVQS VDEKTLYSEA TSLFIKLNPA KSL
- Highest antigen sequence identity to orthologs: Mouse – 70%, Rat – 71%
Target Information
THEM4 (also known as CTMP) binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells.
Hypermethylation of the THEM4 promoter and transcriptional downregulation have been reported in multiple glioblastomas, suggesting an epigenetic role in cancer progression.
Bioinformatic and in vitro analyses indicate that THEM4 functions as a broad-range, high-activity acyl-CoA thioesterase.
Recent studies show that THEM4 is a mitochondrial protein whose overexpression is associated with increased mitochondrial membrane depolarization and caspase-3/PARP cleavage, implicating its involvement in apoptosis.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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