Thermo Fisher Scientific NSD2 Monoclonal Antibody (CL1057)

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:200–1:500

Immunocytochemistry (ICC/IF)

• Tested Dilution: 2–10 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
SANGKTPSCE VNRECSVFLS KAQLSSSLQE GVMQKFNGHD ALPFIPADKL KDLTSRVFNG EPGAHDAKLR FESQEMKGIG TPPNTTPIKN GSPEIKLKIT KTYMNGKPLF ESSICGD

• Highest antigen sequence identity to the following orthologs: Mouse – 91%, Rat – 91%
• Binds to an epitope located within the peptide sequence RVFNGEPGAHDAKLR as determined by overlapping synthetic peptides.

Target Information

This gene encodes a protein that contains four domains present in other developmental proteins: a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. It is expressed ubiquitously in early development. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene maps to the 165 kb WHS critical region and has also been involved in the chromosomal translocation t(4;14)(p16.3;q32.3) in multiple myelomas. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Some transcript variants are nonsense-mediated mRNA (NMD) decay candidates, hence not represented as reference sequences.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.