Thermo Fisher Scientific CD38 Polyclonal Antibody
Human CD38 단백질을 인식하는 Rabbit Polyclonal Antibody로, IHC(P) 등 다양한 연구용 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 제품이며, PBS 안정화 버퍼 포함. 세포막 단백질 CD38 검출 및 림프구 아형 분석에 활용 가능.
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Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 2–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus of CD38 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive Control: Human endometrial adenocarcinoma, tonsil, lymph node
- Cellular Location: Membrane
Target Information
CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein capable of inducing activation, proliferation, and differentiation of mature lymphocytes, as well as mediating apoptosis of myeloid and lymphoid progenitor cells.
CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase, and possibly NAD+ glycohydrolase, or as a cell surface receptor.
Antibodies to CD38 are useful in subtyping lymphomas and leukemias, detection of plasma cells (e.g., identification of myelomas), and as markers for activated B and T cells.
CD38 participates in cell adhesion, signal transduction, and calcium signaling. It is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma, and neuroblastoma.
Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter’s Syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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