Thermo Fisher Scientific IL8 Monoclonal Antibody (1E9)
IL8 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인간 IL8에 반응하며, GST 태그가 포함된 재조합 단백질을 면역원으로 사용했습니다. 액상 형태로 제공되며, PBS 버퍼에 보존제 없이 -20°C에서 보관합니다.
- 카탈로그번호
- H00003576-M04
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 0.1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1E9 |
| Immunogen | IL8 (AAH13615.1, 21–99 a.a.) partial recombinant protein with GST tag (MW of GST tag alone: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB and functions as a chemoattractant and potent angiogenic factor.
IL-8 expression and secretion can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is stored in Weibel-Palade bodies.
Originally isolated from osteosarcoma cells, IL-8 contains the ELR-motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous nomenclature includes:
- Neutrophil activating protein 1 (NAP-1)
- Granulocyte chemotactic protein 1 (GCP-1)
- Monocyte-derived neutrophil-activating peptide (MONAP)
- Protein 3-10C
IL-8 and ten other members of the CXC chemokine gene family form a gene cluster mapped to chromosome 4q.
Cancer studies have demonstrated IL-8’s role in angiogenesis and tumor growth, and it is also implicated in bronchiolitis pathogenesis.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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