Thermo Fisher Scientific IL8 Monoclonal Antibody (6D12)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
EGAVLPRSAK ELRCQCIKTY SKPFHPKFIK ELRVIESGPH CANTEIIVKL SDGRELCLDP KENWVQRVVE KFLKRAENS

Target Information

Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor belonging to the CXC subfamily of chemokines. It binds to cell surface receptors IL-8RA and IL-8RB, functioning as a chemoattractant and potent angiogenic factor.
IL-8 expression and secretion can be induced by various inflammatory stimuli in cells such as macrophages and endothelial cells, where it is stored in Weibel-Palade bodies.
Initially isolated from osteosarcoma cells, IL-8 contains the ELR motif (N-terminal Glu-Leu-Arg sequence) and signals through CXCR1 and CXCR2 receptors.
Previous names include neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP), and protein 3-10C.
IL-8 and related chemokines form a gene cluster on chromosome 4q.
Studies suggest IL-8 plays roles in tumor angiogenesis and growth, as well as in the pathogenesis of bronchiolitis caused by viral infection.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.