Thermo Fisher Scientific Phospho-ALK (Tyr1096) Polyclonal Antibody
Phospho-ALK (Tyr1096) 특이적 폴리클로날 항체로, ALK 단백질의 인산화 상태를 검출합니다. Western blot과 IHC(Paraffin)에서 검증되었으며, 인간, 마우스, 랫트 시료에 반응합니다. 뇌 발달 및 종양 연구에 활용 가능합니다.
- 카탈로그번호
- PA5105238
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALK (Accession Q9UM73), corresponding to amino acid residues around phosphorylated Tyr1096. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816711 |
Product Specific Information
This antibody detects endogenous levels of ALK only when phosphorylated at Tyr1096.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and plays a vital role in brain development.
Mutations, rearrangements, and amplifications in the ALK gene have been identified in various tumors, including anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer.
Chromosomal rearrangements often result in a fusion gene combining the ALK gene (chromosome 2) and the nucleophosmin (NPM) gene (chromosome 5). The NPM-ALK fusion gene product is known to be oncogenic.
ALK encodes a receptor protein-tyrosine kinase with a transmembrane and extracellular domain, showing high sequence similarity to LTK, and is essential for neuronal development and function.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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