Thermo Fisher Scientific Phospho-ALK (Tyr1282, Tyr1283) Polyclonal Antibody
ALK 단백질의 Tyr1282/1283 인산화 상태를 특이적으로 검출하는 Rabbit Polyclonal Antibody. Western blot과 IHC(Paraffin)에 적합하며, 인간, 마우스, 랫트 반응성. 고순도 정제 및 안정한 PBS/glycerol 저장 조건 제공.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human ALK (Accession Q9UM73), corresponding to amino acid residues around phosphorylated Tyr1282 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Sequential chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2816712 |
Product Specific Information
This antibody detects endogenous levels of ALK only when phosphorylated at Tyr1282/1283.
Target Information
Anaplastic Lymphoma Receptor Tyrosine Kinase (ALK) belongs to the insulin receptor superfamily and is vital for brain development. Mutations, rearrangements, and amplifications in the ALK gene are associated with tumors such as anaplastic large cell lymphoma, neuroblastoma, and non-small cell lung cancer. Chromosomal rearrangements often produce fusion genes like NPM-ALK, which have oncogenic properties. ALK possesses transmembrane and extracellular domains absent in NPM-ALK, and shows high sequence similarity to LTK. It plays an essential role in neuronal development and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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