Thermo Fisher Scientific TrkB Polyclonal Antibody
Sheep에서 유래한 TrkB 폴리클로날 항체로, WB 및 IHC에 적합합니다. 마우스 TrkB의 extracellular domain(aa 400-450)에서 합성된 펩타이드를 면역원으로 사용하였습니다. 신경계 관련 연구용으로 적합하며, 장기 보관 시 -20°C에서 안정적으로 보관 가능합니다.
- 카탈로그번호
- OST00118G
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific TrkB Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 10–50 µg/mL |
| Immunohistochemistry (IHC) | 10–50 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Sheep / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide from aa region 400–450 of the extracellular domain of mouse TrkB conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10708408 |
Product Specific Information
- Glycerol (1:1) may be added for additional stability.
- Reconstitute in 500 µL of sterile water.
Target Information
NTRK2 (TRKB) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. NTRK2 is the receptor for brain-derived neurotrophic factor (BDNF). Together, NTRK2 and BDNF regulate both short-term synaptic functions and long-term potentiation of brain synapses.
TrkB is involved in the development and maintenance of the nervous system and is a tyrosine kinase gene highly related to TrkA. Expression is confined to tissues within the central and peripheral nervous systems.
BDNF and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of TrkB gp145, although BDNF elicits a response at least two orders of magnitude greater than NT-3.
TrkB is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through TrkB leads to cell differentiation. Mutations in the TrkB gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for the TrkB gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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