Thermo Fisher Scientific Human MIF Recombinant Protein, PeproTech
인간 MIF 재조합 단백질로, 단핵구 이동 억제 활성을 검증한 연구용 시약입니다. 곤충 세포에서 발현된 His-tag 단백질이며, 순도 ≥98%로 정제되었습니다. 염증과 면역 조절 연구에 적합하며, -20°C에서 보관합니다.
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Applications
Functional Assay (Functional)
- Assay-dependent
In vitro Assay (IV)
- Refer to publications (5 available)
Miscellaneous PubMed (Misc)
- Refer to publications (4 available)
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published Species | Human, Mouse |
| Expression System | Insect cells |
| Amino Acid Sequence | HHHHHHHHAM PMFIVNTNVP RASVPDGFLS ELTQQLAQAT GKPPQYIAVH VVPDQLMAFG GSSEPCALCS LHSIGKIGGA QNRSYSKLLC GLLAERLRIS PDRVYINYYD MNAANVGWNN STFA |
| Tag | His-tag |
| Molecular Weight | 15 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% by SDS-PAGE gel and HPLC analyses |
| Endotoxin Concentration | < 1 EU/µg |
| Activity | Inhibits monocyte migration |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Insect cell-derived Recombinant Human MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please refer to the lot-specific Certificate of Analysis.
Target Information
MIF (macrophage migration inhibitory factor) was one of the first cytokine activities to be discovered and was initially described as a T cell-derived factor that inhibits the random migration of macrophages (Weiser 1989).
Recently, MIF was rediscovered as a pituitary hormone that acts as a counterregulatory hormone for glucocorticoid action within the immune system (Bernhagen 1993, Mitchell 1995).
MIF is released from macrophages and T cells in response to physiological concentrations of glucocorticoids. The secreted MIF counter-regulates the immunosuppressive effects of steroids on immune cell activation and cytokine production (Bucala 1998).
MIF plays a critical role in host control of inflammation and immunity.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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