Thermo Fisher Scientific UVRAG Polyclonal Antibody
UVRAG 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, IP 등 다양한 응용에 사용 가능. 4°C 보관, 액상 형태이며 비결합(Unconjugated) 상태로 제공. 자외선 저항 관련 단백질 연구 및 자가포식 경로 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:100–1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:500 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Item | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 649 and 699 of Human UV radiation resistance associated gene (UVRAG, UniProt ID: Q9P2Y5-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
UVRAG (UV radiation resistance associated gene) is predicted to contain a coiled-coil structure and may be metabolically unstable due to a strong PEST domain. It interacts with Beclin 1, activating autophagy and inhibiting tumorigenicity in human colon cancer cells.
The UVRAG gene is located on chromosome 11q13.5 and complements UV sensitivity in xeroderma pigmentosum group C cells. It is well conserved evolutionarily, suggesting an important role in cellular metabolism.
Chromosomal aberrations involving UVRAG are linked to left-right axis malformation, and mutations are associated with colon cancer. The protein is highly expressed in human brain, lung, kidney, and liver.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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