Thermo Fisher Scientific UVRAG Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000–1:10,000

Immunoprecipitation (IP)

• Tested Dilution: 2–5 µg/mg lysate

Product Specifications

Product Specific Information

The recommended shelf life for this product is 1 year from date of receipt.

Target Information

UVRAG is predicted to contain a coiled-coil structure and is likely to be metabolically unstable based on the occurrence of a strong PEST domain.
It interacts with Beclin 1, leading to activation of autophagy and inhibition of tumorigenicity in human colon cancer cells.
The UVRAG gene is localized on human chromosome 11q13.5 and complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells.
This gene has been well conserved during evolution, implying an important role in cell metabolism.
Chromosomal aberrations involving UVRAG are associated with left-right axis malformation, and mutations have been linked to colon cancer.
The protein is highly expressed in human brain, lung, kidney, and liver.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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