Thermo Fisher Scientific Phospho-DAXX (Ser213) Polyclonal Antibody
Phospho-DAXX (Ser213) 폴리클로날 항체로, 인간 및 생쥐 시료에서 DAXX 단백질의 인산화 상태를 검출. Western blot 및 IHC(파라핀) 실험에 적합. Protein A 및 항원 친화 크로마토그래피로 정제. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S213 of human DAXX |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10986757 |
Product Specific Information
This antibody is predicted to react with mouse and rat based on sequence homology.
Target Information
The DAXX gene encodes a multifunctional protein located in both the nucleus and cytoplasm. It interacts with various proteins, including apoptosis antigen Fas, centromere protein C, and transcription factor E26 oncogene homolog 1. In the nucleus, it acts as a transcription repressor binding to sumoylated transcription factors, with repression relieved upon sequestration into promyelocytic leukemia nuclear bodies or nucleoli. The protein associates with centromeres during G2 phase and may regulate apoptosis in the cytoplasm. Its localization and function are modulated by post-translational modifications such as sumoylation, phosphorylation, and polyubiquitination. Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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