Thermo Fisher Scientific Phospho-CDK2 (Thr160) Polyclonal Antibody
Phospho-CDK2 (Thr160) 특이적 Rabbit Polyclonal Antibody로 인간 CDK2 단백질의 인산화 상태를 검출. Western blot에 최적화되어 있으며, Protein A 및 항원 친화 크로마토그래피로 정제됨. PBS 완충액에 보관하며 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:1,000
- Publications: Refer to Thermo Fisher database for related references
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T160 of human CDK2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10977698 |
Product Specific Information
This antibody is predicted to react with bovine, hamster, mouse, and rat based on sequence homology.
Target Information
CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene, which is localized exclusively in the nucleus. CyclinO shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and are turned over during the cell cycle. The levels of cyclin A-CDK2 are maximal at the G1/S transition, and both CDK2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as a substrate for CDK2-cyclin E and/or CDK2-cyclin A in vivo. CDK2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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