Thermo Fisher Scientific Phospho-CDK2 (Thr160) Polyclonal Antibody

Applications

• Western Blot (WB): Tested dilution 1:1,000
• Publications: Refer to Thermo Fisher database for related references

Product Specifications

Product Specific Information

This antibody is predicted to react with bovine, hamster, mouse, and rat based on sequence homology.

Target Information

CDK2/cyclinO is a member of the cyclin-dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene, which is localized exclusively in the nucleus. CyclinO shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and are turned over during the cell cycle. The levels of cyclin A-CDK2 are maximal at the G1/S transition, and both CDK2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as a substrate for CDK2-cyclin E and/or CDK2-cyclin A in vivo. CDK2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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