Thermo Fisher Scientific Factor VII Polyclonal Antibody
Factor VII 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 적용 가능. 인간 및 생쥐 반응성. 고순도 항원 친화 크로마토그래피 정제 제품으로 연구용 적합.
- 카탈로그번호
- PA521346
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 209–466 of Factor VII (Uniprot ID: P08709) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2.32 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11152684 |
Product Specific Information
- Recommended positive controls: human plasma, NIH-3T3
- Predicted reactivity: Rhesus Monkey (91%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Coagulation factor VII is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form and is converted to an active form by factor IXa, factor Xa, factor XIIa, or thrombin via minor proteolysis. Upon activation, a heavy chain containing a catalytic domain and a light chain containing two EGF-like domains are generated, held together by a disulfide bond. In the presence of factor III and calcium ions, activated factor VII further activates the coagulation cascade by converting factor IX to IXa and/or factor X to Xa. Defects in F7 production can lead to coagulopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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