Thermo Fisher Scientific Insulin Receptor Polyclonal Antibody, Biotin
인슐린 수용체를 인식하는 Biotin 결합 폴리클로날 항체로, Western blot, ELISA, IP에 적합합니다. 사람, 마우스, 랫트 시료에 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
- 카탈로그번호
- INSR1-BIOTIN
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 900–950 on human Insulin receptor (transcript variant 2). Cross-reactive with both insulin receptor α and β variants. |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA and 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
INSR (Insulin Receptor) is a receptor tyrosine kinase that mediates the biological effects of insulin. Binding of insulin to the extracellular domain stimulates glucose uptake. INSR and IGF-1 receptors share significant structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine residues in INSR. In humans, the INSR gene is located on chromosome 19. Defects in INSR are associated with various insulin resistance syndromes, while IGF-1R defects can lead to certain growth retardation disorders.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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