Thermo Fisher Scientific VIM Monoclonal Antibody (OTI13B1), TrueMAB
Vimentin 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. Luminex 등 다양한 분석에 사용 가능하며, 고순도의 액상 항체입니다. PBS 버퍼에 보존되어 있으며, -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Applications
- Luminex (LUM): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI13B1 |
| Immunogen | Full length human recombinant protein of human VIM produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with <5% trehalose |
| Contains | 0.05% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
Target Information
Vimentin is a developmentally regulated intermediate filament protein (IFP) found in cells of mesenchymal origin. It is believed to be involved with the intracellular transport of proteins between the nucleus and plasma membrane. Unlike other IFP proteins, vimentin is expressed, along with desmin, during the early stages of cellular development. During the development process, vimentin is exchanged for new, tissue-specific IFPs.
Vimentin has been implicated to be involved in the rate of steroid synthesis via its role as a storage network for steroidogenic cholesterol-containing lipid droplets. Vimentin phosphorylation by a protein kinase causes the breakdown of intermediate filaments and activation of an ATP and myosin light chain-dependent contractile event. This results in cytoskeletal changes that facilitate the interaction of lipid droplets within mitochondria, leading to increased steroid synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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