Thermo Fisher Scientific SAV1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunogen sequence:
IGRVAATSLG NLTNHGSEDL PLPPGWSVDW TMRGRKYYID HNTNTTHWSH PLEREGLPPG WERVESSEFG TYYVDHTNKK AQYRHPCAPS VPRYDQPPPV TYQPQQTERN QSLLVPANPY HTAEIPDWLQ VYARAPVKYD HILKWELFQL A

Highest antigen sequence identity to the following orthologs:

• Mouse: 98%
• Rat: 98%

Target Information

Sav1 is a regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway, which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylate and activate LATS1/2 with its regulatory protein MOB1. This in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ.
Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration.
SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
It also plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes and its ability to phosphorylate CROCC and CEP250.
In conjunction with STK3/MST2, Sav1 activates the transcriptional activity of ESR1 through the modulation of its phosphorylation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.