Thermo Fisher Scientific ZNF268 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:500

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human ZNF268. Recombinant protein control fragment (Product #RP-99712). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:ZNF268,uniProtId:Q14587-1,ncbiNodeId:9606,antigenRange:144-264,antigenLength:947,antigenImageFileName:PA5-51637_ZNF268_Q14587-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51637_ZNF268_Q14587-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2650033

Product Specific Information

Immunogen sequence: AQVPNQTCPN TVWKIDDLMD WHQENKDKLG STAKSFECTT FGKLCLLSTK YLSRQKPHKC GTHGKSLKYI DFTSDYARNN PNGFQVHGKS FFHSKHEQTV IGIKYCESIE SGKTVNKKSQ L

Highest antigen sequence identity to the following orthologs: Mouse - 27%, Rat - 26%.

Target Information

Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a krueppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. Zinc finger protein 268 (ZNF268), also known as zinc finger protein 3 or HZF3, is a 947 amino acid protein belonging to the krueppel C2H2-type zinc-finger protein family. ZNF268 contains 24 C2H2-type zinc fingers and one KRAB domain. Localized to the nucleus, ZNF268 is involved in transcriptional regulation and is highly expressed in three to five week old embryos. ZNF268 has been implicated in human leukemia, due to the identification of an alternatively spliced form in leukemia patients. Two named isoforms of ZNF268 exist as a result of alternative splicing events.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.