Thermo Fisher Scientific TRAcP (Tartrate-Resistant Acid Phosphatase) Monoclonal Antibody (ACP5, 1070)

Applications

• Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

Tartrate-resistant acid phosphatase (TRAP) is a basic iron-binding protein with high activity toward phosphoproteins, ATP, and 4-nitrophenyl phosphatase.
It is detected in human alveolar macrophages, osteoclasts, spleen, and liver.
Expression increases in:

• Spleen and monocytes of patients with Gaucher’s disease
• Spleenocytes and circulating leukocytes of patients with hairy cell leukemia
• Spleen of patients with Hodgkin’s lymphoma
• Sera of patients undergoing active bone turnover

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.