Thermo Fisher Scientific RRAS Polyclonal Antibody

Thermo Fisher Scientific RRAS Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Recommended positive controls: H1299, HeLaS3, Molt-4, Raji, Neuro 2A, C8D30, NIH-3T3, Raw264.7, C2C12, PC-12, Rat2
• Predicted reactivity: Mouse (93%), Rat (91%), Bovine (96%)
• Store product as a concentrated solution and centrifuge briefly prior to opening the vial.

Target Information

The Ras superfamily of small GTPases includes Ras, Rho, Arf, Rab, and Ran families. Ras-regulated signaling pathways control actin cytoskeletal integrity, proliferation, differentiation, cell adhesion, apoptosis, and cell migration. These GTPases function as molecular switches cycling between GDP-bound inactive and GTP-bound active forms. Mutations in Ras proto-oncogenes (H-Ras, N-Ras, K-Ras) are common, found in 20–30% of all human tumors.
K-Ras mutations occur frequently in non-small-cell lung, colorectal, and pancreatic carcinomas; H-Ras mutations are common in bladder, kidney, and thyroid carcinomas; N-Ras mutations are found in melanoma, hepatocellular carcinoma, and hematologic malignancies.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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