Thermo Fisher Scientific PRKAR2B Polyclonal Antibody
PRKAR2B 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC 등 다양한 응용에 사용 가능. Human, Mouse, Rat 반응성. 항원 친화 크로마토그래피로 정제된 고품질 항체.
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Thermo Fisher Scientific PRKAR2B Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:100–1:1,000 | - |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | - |
Product Specifications
| Specification | Details |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 177–391 of Human PKA 2 beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.67 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2545742 |
Product Specific Information
- Recommended positive controls: HeLa, HepG2, mouse brain, rat brain
- Predicted reactivity: Mouse (97%), Rat (96%), Xenopus laevis (84%), Bovine (99%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
cAMP is a signaling molecule important for a variety of cellular functions. It activates cAMP-dependent protein kinase, which transduces signals through phosphorylation of target proteins. The inactive kinase holoenzyme consists of two regulatory and two catalytic subunits. Upon activation, cAMP causes dissociation into a regulatory dimer and free catalytic monomers.
This gene encodes one of the regulatory subunits, which can be phosphorylated by the activated catalytic subunit. It interacts with and suppresses CREB1 transcriptional activity in activated T cells. Knockout studies in mice indicate this subunit’s role in regulating energy balance and adiposity, and in mediating gene induction and cataleptic behavior induced by haloperidol.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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