
Thermo Fisher Scientific DKK1 Recombinant Rabbit Monoclonal Antibody (1D12)
인간 DKK1 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 등 다양한 응용에 적합함. HEK293 세포에서 발현되었으며, 고순도의 액상 형태로 제공됨. Wnt/β-catenin 신호 억제 연구에 유용함.
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Applications
- Western Blot (WB): 1:500–1:5,000
- Tested in direct-ELISA
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 1D12 |
| Immunogen | A synthesized peptide derived from human DKK1 (UniProt ID: O94907-1, antigen range: 246–260) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol, 150 mM NaCl |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C or −80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_2898278 |
Product Specific Information
This antibody has been tested in direct-ELISA.
Target Information
DKK-1 is a member of the DKK protein family, which includes DKK-2, DKK-3, and DKK-4. It was originally identified as a Xenopus head-forming molecule that acts as an antagonist for Wnt signaling. DKK-1 and DKK-4 regulate the Wnt/β-catenin signaling pathway by forming inhibitory complexes with LRP5 and LRP6, key co-receptors in this system. By inhibiting Wnt/β-catenin signaling, DKK-1 supports anterior development. Mice lacking DKK-1 expression fail to form heads and die during embryogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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