Thermo Fisher Scientific IL17C Polyclonal Antibody, Biotin
IL17C 단백질을 인식하는 Biotin 결합 토끼 다클론 항체로, Western blot, IHC, ELISA, IP에 사용 가능. 사람 및 비인간 영장류 반응성. 친화 크로마토그래피 정제, -20°C 보관. 연구용으로만 사용.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to IL17RC protein common to C1, C2, C5, C8, C9, C11, C12 isoforms |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cytokine that plays a crucial role in innate immunity of the epithelium, including against intestinal bacterial pathogens, in an autocrine manner. It stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergistically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A, and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, IL17C may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting an inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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