Thermo Fisher Scientific IL17C1 Polyclonal Antibody, Biotin
IL17RC1 단백질을 인식하는 Biotin 결합 폴리클로날 항체. Western blot, ELISA, IP 등 다양한 응용 가능. 인간 및 비인간 영장류 반응성. 고순도 Affinity chromatography로 정제된 제품으로 연구용에 최적화.
- 카탈로그번호
- IL17RC1-BIOTIN
- 판매단위
- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 1:50–1:250
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 70–120 on IL17RC1 protein common to C2 and C5 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8) with 0.5% BSA, 30% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity.
Acts as a receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA. Also binds IL17A–IL17F heterodimer and IL17F homodimer, triggering TRAF6 and NF-κB signaling pathways.
Induces transcriptional activation of IL33, promoting sympathetic innervation and immune responses.
Binding of IL17A–IL17F to IL17RA–IL17RC complex activates TRAF6-mediated NF-κB and MAPK pathways, leading to cytokine and chemokine expression and antimicrobial peptide production.
Primarily induces neutrophil activation and recruitment at infection and inflammation sites, and stimulates mucosal epithelial cells to produce antimicrobial β-defensins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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