Thermo Fisher Scientific KLF17 Polyclonal Antibody
KLF17 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot 및 ELISA에 적합하며, 인간과 마우스 반응성. 핵 내 KLF17 단백질 검출용으로 사용. -20°C 보관, 0.53 mg/mL 농도, PBS/glycerol buffer.
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Thermo Fisher Scientific KLF17 Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:2,000
- ELISA: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing sequence corresponding to amino acids 210–389 of human KLF17 (NP_7757553) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.53 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805549 |
Product Specific Information
- Immunogen sequence:
QMLPPQDAHD LGMPPAESQS LLVLGSQDSL VSQPDSQEGP FLPEQPGPAP QTVEKNSRPQ EGTGRRGSSE ARPYCCNYEN CGKAYTKRSH LVSHQRKHTG ERPYSCNWES CSWSFFRSDE LRRHMRVHTR YRPYKCDQCS REFMRSDHLK QHQKTHRPGP SDPQANNNNG EQDSPPAAGP - Positive Samples: U-87MG, HepG2, MCF7, Mouse brain
- Cellular Location: Nucleus
Target Information
KLF17 is a transcription repressor that binds to the promoter of target genes and prevents their expression. It acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and represses its expression. It may also function as a germ cell-specific transcription factor involved in spermatid differentiation and oocyte development.
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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