Thermo Fisher Scientific ZBP1 Polyclonal Antibody
ZBP1 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. WB, IHC, IP 등 다양한 응용에 사용 가능. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific ZBP1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2.0 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 20 µg/mL | – |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | – |
| Immunoprecipitation (IP) | – | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid synthetic peptide from near the carboxy terminus of human ZBP1. The immunogen is located within the last 50 amino acids of ZBP1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154181 |
Product Specific Information
- Suggested positive controls: mouse small intestine or human small intestine tissue lysate
- PA5-20455 can be used with blocking peptide PEP-0572
- Detects ZBP1 in WB application with human samples
Target Information
Z-DNA binding protein 1 (ZBP1) belongs to a family of proteins that contain the Zalpha domain, which binds specifically to left-handed Z-DNA and Z-RNA.
ZBP1 was initially identified as a novel gene up-regulated in activated macrophages in mice bearing ascites tumors, suggesting a role in host response during neoplasia.
Recent studies indicate that cytosolic ZBP1 can act similarly to toll-like receptor TLR9 by detecting cytosolic double-stranded DNA and inducing type I interferon and innate immune responses.
Binding of ZBP1 to dsDNA enhances its association with innate immune response proteins such as IRF3 and TBK1 (NAK).
Multiple isoforms of ZBP1 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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