Thermo Fisher Scientific NUP107 Recombinant Rabbit Monoclonal Antibody (8E6H4)
NUP107 단백질을 인식하는 재조합 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. HEK293 세포 발현 시스템에서 생산되며, 고순도 Protein A 정제 방식으로 제공됩니다. 인간과 랫트 반응성이 있으며, 액상 형태로 안정적인 보관이 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:100–1:500
ELISA
- Tested Concentration: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8E6H4 |
| Immunogen | Synthetic peptide corresponding to amino acids 700–800 of human Nup107 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20 °C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
LASKKHEAAK EVFVKIPQDS IAEIYNQCEE QGMESPLPAE DDNAIREHLC IRAYLEAHET FNEWFKHMNS VPQKPALIPQ PTFTEKVAHE HKEKKYEMDF G
Target Information
The nuclear pore complex (NPC) is a protein assembly localized at the nuclear rim and mediates macromolecular transport between the nucleus and the cytoplasm. The mammalian nucleoporin (NUP)-107 is part of the hetero-oligomeric complex that also contains NUP160, NUP133, NUP96, and mammalian homolog of yeast sec13p.
While most of the NUP107-160 nuclear pore sub-complex localizes to the nuclear pore, a small fraction is observed at kinetochores and pro-metaphase spindle poles in mitotic cells, associated with proteins such as Mad1, Mad2, Bub3, and Cdc20.
Immunodepletion of the NUP107-160 complex results in defective spindle assembly, indicating multiple functions. NUP107 has been identified as an HIV dependency factor (HDF), suggesting its potential as a drug target in HIV treatment. Multiple isoforms of NUP107 are known to exist.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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