Thermo Fisher Scientific PDHA1 Recombinant Rabbit Monoclonal Antibody (5N5W8)
Recombinant Rabbit Monoclonal Antibody targeting PDHA1 for WB and ELISA applications. Reacts with human and mouse. Expressed in HEK293 cells, purified via Protein A. Supplied in PBS buffer with glycerol and BSA for stable storage at -20°C.
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- MA555220
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:5,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5N5W8 |
| Immunogen | A synthetic peptide corresponding to amino acids 248–348 of human PDHA1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.26 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
IPGLRVDGMD ILCVREATRF AAAYCRSGKG PILMELQTYR YHGHSMSDPG VSYRTREEIQ EVRSKSDPIM LLKDRMVNSN LASVEELKEI DVEVRKEIED
Target Information
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the conversion of pyruvate to acetyl-CoA and CO₂, linking glycolysis to the tricarboxylic acid (TCA) cycle. The PDH complex consists of multiple copies of three enzymatic components:
- Pyruvate dehydrogenase (E1)
- Dihydrolipoamide acetyltransferase (E2)
- Lipoamide dehydrogenase (E3)
The E1 enzyme is a heterotetramer of two alpha and two beta subunits. The PDHA1 gene encodes the E1 alpha 1 subunit, which contains the E1 active site and is essential for PDH complex function. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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