Thermo Fisher Scientific RAMP2 Polyclonal Antibody
RAMP2 단백질을 인식하는 토끼 폴리클로날 항체로, Western blot 및 파라핀 포매 조직 면역염색에 적합합니다. 인간, 마우스, 랫트 반응성이 있으며, 고순도의 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human RAMP2 (Accession O60895), corresponding to amino acid residues A24–D74 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852083 |
Product Specific Information
Antibody detects endogenous levels of total RAMP2.
Target Information
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs).
RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus.
They are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane.
CRLR can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which RAMP family members are expressed.
In the presence of RAMP2, CRLR functions as an adrenomedullin receptor.
RAMP2 is involved in core glycosylation and transportation of the adrenomedullin receptor to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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