Thermo Fisher Scientific TRAF7 Polyclonal Antibody
TRAF7 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체입니다. Western blot 및 IHC(P)에서 검증되었으며, 인간, 마우스, 랫트 시료에 반응합니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공되며 -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TRAF7 (Accession Q6Q0C0), corresponding to amino acid residues A37–D87. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852087 |
Product Specific Information
Antibody detects endogenous levels of total TRAF7.
Target Information
TRAFs are signal transducers for members of the TNFR superfamily, critically involved in activation of MAP3K family members that mediate NF-kappaB and JNK activation and apoptosis.
TRAF7, a 670 amino acid protein, is a human homolog of mouse Traf7. It contains an N-terminal RING finger domain, central TRAF domain, a coiled-coil motif, and seven WD40 repeats at the C-terminus.
It exhibits E3-ubiquitin ligase activity for self-ubiquitination and specifically interacts with MEKK3 to mediate AP1 and CHOP activation, inducing apoptosis through Caspase-independent pathways.
TRAF7 also participates in sumoylation and negative regulation of c-Myb, influencing proliferation and differentiation of hematopoietic cells.
Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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