Thermo Fisher Scientific CACNA1A Polyclonal Antibody
Rabbit polyclonal antibody targeting human CACNA1A, validated for WB and IHC applications. Recognizes voltage-dependent calcium channel alpha-1A subunit. Lyophilized form, reconstitute in sterile water. Suitable for neuroscience and calcium signaling r...
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- OSC00079W-100UL
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | - |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from aa region 1000–1050 of human CACNA1A conjugated to carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long-term, store at -20°C. Avoid freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Antigen shares 87% identity with mouse and rat sequence.
- Specificity: CACNA1A.
Target Information
Voltage-dependent calcium channels mediate calcium ion entry into excitable cells and regulate processes such as muscle contraction, neurotransmitter release, and gene expression. These channels consist of multiple subunits, with the alpha-1 subunit forming the pore and determining channel type.
The CACNA1A gene encodes the alpha-1A subunit, primarily expressed in neuronal tissue. Mutations in CACNA1A are linked to familial hemiplegic migraine and episodic ataxia type 2. Polymorphic variations with expanded polyglutamine tracts are associated with spinocerebellar ataxia type 6.
Multiple transcript variants exist, differing in the 3′ UTR and coding regions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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