Thermo Fisher Scientific INSR Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Positive test controls include: HepG2, HeLa, Mouse brain, Mouse kidney.
The target is usually found in the following locations: Cell membrane, Single-pass type I membrane protein.

Immunogen sequence:
PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN PS

Target Information

INSR is a receptor tyrosine kinase. Binding of insulin to the extracellular domain of INSR stimulates glucose uptake. INSR and IGF-1 receptors share major structural and functional similarity. The earliest cellular response to insulin stimulation is autophosphorylation of tyrosine in INSR.
In humans, the INSR gene is located on chromosome 19.
Defects in INSR are associated with various insulin resistance syndromes, and IGF-1R defects may also cause some forms of growth retardation.

Safety Information

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.