Thermo Fisher Scientific Lamin B1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

1:50-1:200

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 397-586 of human Lamin B1 (NP_0055641) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Lamin B1,uniProtId:P20700-1,ncbiNodeId:9606,antigenRange:397-586,antigenLength:586,antigenImageFileName:PA5-120503_Lamin_B1_P20700-1_Rabbit.svg,antigenImageFileNamePDP:PA5-120503_Lamin_B1_P20700-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

2.54 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2914075

Product Specific Information

Positive test controls include: Jurkat, Mouse spleen, Rat liver. The target is usually found in the following locations: Lipid-anchor, Nucleoplasmic side, Nucleus inner membrane.

Immunogen sequence: RVTVSRASSS RSVRTTRGKR KRVDVEESEA SSSVSISHSA SATGNVCIEE IDVDGKFIRL KNTSEQDQPM GGWEMIRKIG DTSVSYKYTS RYVLKAGQTV TIWAANAGVT ASPPTDLIWK NQNSWGTGED VKVILKNSQG EEVAQRSTVF KTTIPEEEEE EEEAAGVVVE EELFHQQGTP RASNRSCAIM

Target Information

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Defects in the LMNB1 gene can cause Leukodystrophy, demyelinating, autosomal dominant, adult-onset (ADLD).

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.