Thermo Fisher Scientific Phospho-c-Fos (Thr232) Polyclonal Antibody
인간 c-Fos 단백질의 Thr232 인산화 부위를 인식하는 Rabbit Polyclonal 항체입니다. Western blot, IHC, ICC/IF, ChIP 등 다양한 응용에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, -20°C에서 보관합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20 | - |
| Immunocytochemistry (ICC/IF) | 1:250 | - |
| ChIP assay (ChIP) | 1–3 µg × 10⁶ cells | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human c-Fos that contains threonine 232. The sequence is conserved in mouse and rat. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533621 |
Target Information
FBJ murine osteosarcoma viral oncogene homolog, commonly known as Cellular proto-oncogene Fos (c-Fos), belongs to the Fos transcription factor family and is encoded by the C-FOS gene on chromosome 14.
c-Fos forms a heterodimer with c-Jun to create the Activator Protein-1 (AP-1) transcription factor, which regulates gene transcription involved in cell signaling, proliferation, and differentiation.
Phosphorylation of c-Fos occurs at multiple sites in response to growth factors and insulin. The ERK MAPK kinase phosphorylates threonine 232, controlling c-Fos nuclear localization and transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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