Thermo Fisher Scientific Phospho-MYLK (Ser19) Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Target Information

MYLK (MLCK) is a serine/threonine kinase that phosphorylates myosin regulatory light chains to assist in the production of contractile activity (myosin-actin interaction).
MLCK is responsible for smooth muscle contraction via phosphorylation of a specific serine in the N-terminus of myosin light chains (MLC), facilitating myosin interaction with actin filaments.
It plays a central role in vascular permeability, tissue edema formation, and regulation of astrocytic process growth and neurotransmitter release in the nervous system.
MLCK also participates in fibroblast apoptosis signaling pathways. Smooth muscle and non-muscle isozymes are expressed in a wide range of tissues, with the non-muscle isoform 2 being the dominant splice variant.
The Telokin isoform binds calmodulin and is widely distributed in adult and fetal tissues. MLCK activity is likely down-regulated by phosphorylation and the protein contains one fibronectin type III domain and nine immunoglobulin-like C2-type domains.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.