Thermo Fisher Scientific CCKAR Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

PA3-116 detects CCK1-Receptor in human samples.
It has been successfully used in Western blot, immunocytochemistry, and immunohistochemistry procedures.
By Western blot, this antibody detects an ~80–90 kDa protein representing CCK1-Receptor in human samples.
In immunohistochemistry, PAC1 immunoreactivity is predominantly localized at the plasma membrane and in cells of the gastric mucosa, myenteric ganglion cells, and myenteric nerve fibers in the gastrointestinal tract.

PA3-116 immunogen is a synthetic peptide, KLH conjugated, corresponding to the residues T(409)–Q(428) of human VPAC2 receptor.

Target Information

This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin family of peptide hormones.
This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach.
In the central and peripheral nervous system, this receptor regulates satiety and the release of beta-endorphin and dopamine.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.